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Doxorubicin Hydrochloride

MedicaPharma is your trusted source of top-quality Doxorubicin Hydrochloride (HCL) manufactured in accordance with Good Manufacturing Practices (GMP)

MedicaPharma is a reputable API distributor that supplies global pharmaceutical customers such as hospitals, compounding pharmacies, and universities according to Good Distribution Practices (GDP) regulations.

We support you with an extensive range of niche APIs produced by GMP-certified manufacturers worldwide.

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About Doxorubicin

Doxorubicin HCL is a cancer treatment administered through intravenous injection. Also known as hydroxydaunorubicin and hydroxydaunomycin, it is used in cancer management to treat various cancer types, including bladder cancer, Kaposi’s sarcoma, breast cancer, lymphoma, and acute lymphocytic leukemia. 

Regulatory Approval

Doxorubicin HCL was approved in the United States in 1974 and is on the World Health Organization’s List of Essential Medicines. In March 2022, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a favorable opinion of the drug Zolsketil, a branded doxorubicin product. The statement recommended that the drug receive a marketing authorization to treat advanced ovarian cancer, progressive multiple myeloma, metastatic breast cancer, and AIDS-related Kaposi’s sarcoma.

Doxorubicin HCL is typically combined with other chemotherapy agents to achieve desired treatment results.

How Doxorubicin HCL Works

Doxorubicin interacts with DNA through intercalation (inserting or placing a molecule or compound between the base pairs of a DNA or RNA molecule) and inhibiting macromolecular biosynthesis. Both mechanisms hinder the activity of topoisomerase II – an enzyme responsible for relaxing supercoils in DNA during transcription. Doxorubicin stabilizes the topoisomerase II complex after the DNA chain is broken for replication, and this prevents the release of the DNA double helix, effectively stopping the replication process. Doxorubicin also enhances the production of quinone-type free radicals, which contributes to its cytotoxic effects.

The doxorubicin molecule contains a planar aromatic chromophore segment that inserts itself between two DNA base pairs. Concurrently, the six-membered daunosamine sugar portion occupies the minor groove and interacts with adjacent base pairs next to the intercalation site. Doxorubicin can induce the eviction of histones from transcriptionally active chromatin through its intercalation mechanism. As a result, cells exposed to doxorubicin experience deregulation in DNA epigenome, transcriptome, and damage response.

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Why Buy GMP-Certified Products?

GMP-certified products are produced and controlled according to standards set by regulatory authorities and relevant industry organizations. 

Quality Assurance

Safety and Efficacy

GMP is a mark of quality. Compliance with GMP standards ensures products are manufactured to high standards, including consistency, equipment, employee training, testing, and facility design. 

GMP-certified products undergo robust quality control and testing procedures to ensure they are consistent, safe, and effective. This is absolutely critical for substances intended for human consumption. 

Regulatory Compliance

Supply Chain Reliability

GMP is recognized worldwide as the leading standard for producing and distributing APIs. Many regulatory authorities, including the European Medicines Agency (EMA), and the US Food and Drug Administration (FDA) require GMP compliance for product approval and marketing.

GMP covers the entire supply chain to make sure your products are top quality from start to finish, including raw material sourcing, storage, and transportation. Choosing GMP-certified APIs ensures supply chain integrity and reduced risk of poor-quality, counterfeit, or contaminated products.

Doxorubicin HCL Research

Research associated with doxorubicin HCL includes:

Anti-Cancer Activity

Research exploring the effects of doxorubicin HCL produced favorable endpoints, specifically combination therapy experiments using sirolimus to treat Akt-positive lymphomas in mice. 

Further, doxorubicin was combined with a murine monoclonal antibody in a 2006 animal study. This research led to the development of a specialized type of therapeutic agent designed to selectively target and deliver a cytotoxic drug (immunoconjugate) that eliminated HIV-1 infection in mice.

Potential Antimalarial Uses

Evidence from 2009 suggests that doxorubicin and related compounds may have antimalarial properties. The study found that a compound structurally similar to doxorubicin demonstrated the potential to inhibit plasmepsin II.

Plasmepsin II is an enzyme unique to the malarial parasite Plasmodium falciparum. Following the discovery, the pharmaceutical company GlaxoSmithKline identified doxorubicin as one of the compounds that has the potential to prevent malarial parasite growth. 

Potential as a Theranostic Agent

A theranostic (therapeutic and diagnostic) agent is a type of multifunctional compound or substance that combines both characteristics into a single product. 

Doxorubicin is known for its fluorescence characteristics, where certain substances can absorb light at a specific wavelength while emitting light at a longer wavelength. These properties have been used to assess doxorubicin’s potential as a theranostic agent, however the compound’s fluorescence spectrum depends on certain factors, such as the solvent dielectric constant and the environment’s pH.

Why MedicaPharma ?

MedicaPharma is a trusted and fully licenced API distributor based in Europe that leverages a global network of GMP manufacturers to supply high-quality API’s and pharmaceutical intermediates to healthcare organizations all over the world. 

Different countries and jurisdictions may have varying regulatory requirements, with poor enforcement of relevant rules and regulations. There may be accountability and transparency issues associated with manufacturing and distribution, which increases your risk of receiving non compliant products. 

All MedicaPharma APIs are being checked within a closed GDP logistics circuit; in – and outgoing checks secure the quality and supply of the right material.

Leverage Our Network of 400+ GMP Manufacturers​

Access High-Quality Chemicals Produced to GMP Standards

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MedicaPharma partners with over 400 leading global producers to supply hospitals, pharmacies, research facilities, and educational institutions.

All our products are produced in regulated, GMP-compliant facilities and shipped with original documentation. No repacking or relabeling. 

MedicaPharma is committed to providing trust, accountability, and transparency. We guarantee our products and support you from start to finish with first-in-class customer service.

Get a Doxorubicin Quote

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Frequently Asked Questions

Farmitalia Research Laboratories, an Italy-based research company, initially conducted research to learn if anticancer compounds could be found in soil-based microbes. Researchers found a new strain of Streptomyces peucetius and discovered that this bacterium was effective against tumors in mice. It was later named daunorubicin, a product that was later developed into doxorubicin.

Researchers initially discovered that minor structural changes to daunorubicin could result in changes in its biological activity and mutated a strain of Streptomyces using N-nitroso-N-methyl urethane to produce a novel antibiotic, which was eventually named doxorubicin.

Doxorubicin HCL is available at MedicaPharma – a reputable, experienced supplier of APIs to pharmacies, hospitals, research, and educational institutions. Click here for a free quote.

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