About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Doxifluridine is an oral prodrug of 5fluorouracil (5FU). It undergoes conversion by pyrimidine phosphorylase, which is highly expressed in tumour tissue, generating cytotoxic 5FU locally. 5FU inhibits thymidylate synthase and incorporates into RNA and DNA, disrupting replication and transcription.
Benefits and Advantages
Used in tumourtargeted prodrug research, pyrimidinepathway studies, 5FU activation assays, oncologymodel development and nucleotideantimetabolite mechanism analysis.
Side Effects and Risks
Risks include myelosuppression, mucositis, GI toxicity, cardiotoxicity (rare) and dermatologic reactions. Handle with cytotoxicantimetabolite precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C9H11FN2O5 |
|---|---|
| Molecular Weight | 246.19 g/mol |
| CAS Number | 436349 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | >36.9 [ug/mL] (The mean of the results at pH 7.4) |
| Purity | Purity information is available upon request (COA). |
| Synonym | doxifluridine; 5'-Deoxy-5-fluorouridine; 5-fluoro-5'-deoxyuridine; Furtulon; 3094-09-5 |
| IUPAC/Chemical Name | 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoropyrimidine-2,4-dione |
| InChl Key | ZWAOHEXOSAUJHY-ZIYNGMLESA-N |
| InChl Code | InChI=1S/C9H11FN2O5/c1-3-5(13)6(14)8(17-3)12-2-4(10)7(15)11-9(12)16/h2-3,5-6,8,13-14H,1H3,(H,11,15,16)/t3-,5-,6-,8-/m1/s1 |
| References |
3D Conformer.
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