About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
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Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Cytarabine (Ara‑C) is a pyrimidine nucleoside analogue that is phosphorylated to Ara‑CTP, which competitively inhibits DNA polymerase and is incorporated into DNA, terminating chain elongation. It is highly specific for S‑phase cells.
Benefits and Advantages
Used in leukemia‑model research, DNA‑polymerase inhibition studies, nucleoside‑metabolism modelling, cell‑cycle analysis, and apoptosis investigations.
Side Effects and Risks
Risks include severe myelosuppression, neurotoxicity, ocular toxicity, GI damage and immunosuppression. Handle with strict cytotoxic‑agent containment.
Datasheet
| Molecular Formula | C9H13N3O5 |
|---|---|
| Molecular Weight | 243.22 g/mol |
| CAS Number | 147-94-4 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Freely soluble |
| Purity | Purity information is available upon request (COA). |
| Synonym | cytarabine; 147-94-4; Ara-C; Cytosine arabinoside; Aracytidine |
| IUPAC/Chemical Name | 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one |
| InChl Key | UHDGCWIWMRVCDJ-CCXZUQQUSA-N |
| InChl Code | InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7+,8-/m1/s1 |
| References |
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