About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Cyclophosphamide is an alkylating prodrug activated by hepatic CYP450 enzymes into phosphoramide mustard and acrolein. Phosphoramide mustard crosslinks DNA at the N7 position of guanine, disrupting replication and triggering apoptosis. It is active against rapidly dividing malignant and immune cells.
Benefits and Advantages
Used in cancercytotoxicity modelling, DNAcrosslinking research, immunosuppression pathway studies, cellcycle arrest experiments and alkylatingagent SAR analysis.
Side Effects and Risks
Risks include myelosuppression, hemorrhagic cystitis (via acrolein), infertility, cardiotoxicity, immunosuppression and secondary malignancies. Handle under strict cytotoxicdrug containment.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C7H15Cl2N2O2P |
|---|---|
| Molecular Weight | 261.08 g/mol |
| CAS Number | 50-18-0 |
| Storage Condition | Cyclophosphamide should be preserved in tight containers, at a temperature between 2 & 32 °C. |
| Solubility | 10 to 50 mg/mL at 73 °F (NTP, 1992) |
| Purity | Purity information is available upon request (COA). |
| Synonym | cyclophosphamide; 50-18-0; Cytoxan; Cyclophosphamid; Cyclophosphane |
| IUPAC/Chemical Name | N,N-bis(2-chloroethyl)-2-oxo-1,3,2lambda5-oxazaphosphinan-2-amine |
| InChl Key | CMSMOCZEIVJLDB-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C7H15Cl2N2O2P/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14/h1-7H2,(H,10,12) |
| References |
3D Conformer.
(Click, turn or enlarge)
Download our GMP API Product List.
MedicaPharma is an EU-based supplier of GMP-certified APIs that serves leading healthcare institutions and research organizations.
Click here to download our full API product list.
