About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Clofarabine is a second‑generation purine nucleoside analogue that inhibits DNA polymerase, ribonucleotide reductase and induces mitochondria‑mediated apoptosis. It incorporates into DNA and disrupts elongation, causing lethal DNA damage in rapidly dividing cells.
Benefits and Advantages
Used in acute‑leukemia modelling, purine‑analogue pathway research, apoptosis studies, nucleotide‑metabolism analysis and DNA‑damage response investigations.
Side Effects and Risks
Risks include myelosuppression, hepatotoxicity, capillary‑leak syndrome, systemic infections and renal impairment. Handle with full cytotoxic‑drug containment.
Datasheet
| Molecular Formula | C10H11ClFN5O3 |
|---|---|
| Molecular Weight | 285.68 g/mol |
| CAS Number | 123318-82-1 |
| Storage Condition | Store in a cool, dry place; protect from light |
| Solubility | Soluble in water |
| Purity | Purity information is available upon request (COA). |
| Synonym | Clofarabine; 123318-82-1; Clolar; Evoltra; Clofarex |
| IUPAC/Chemical Name | 2-chloro-9-(2-deoxy-β-D-erythropentofuranosyl)-9H-purin-6-amine |
| InChl Key | Unavailable |
| InChl Code | Unavailable |
| References | PubChem; ChemBL; FDA; |
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