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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
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Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of action
Carmofur is a lipophilic fluoropyrimidine derivative and prodrug of 5fluorouracil (5FU). It inhibits thymidylate synthase, depleting dTMP required for DNA synthesis, and incorporates into RNA to disrupt transcription. Carmofur also inhibits acid ceramidase, accumulating ceramide and inducing apoptosis through sphingolipidmediated pathways.
Benefits and advantages
Used in anticancer research, fluoropyrimidinepathway studies, thymidylatesynthase inhibition assays, sphingolipidsignalling research, apoptosis modelling, colorectalcancer studies and chemoresistance analysis.
Side effects and risks
Risks include myelosuppression, diarrhoea, mucositis, hepatotoxicity, neurotoxicity and dermatologic reactions. Handle with cytotoxiccompound containment.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C11H15FN2O3 |
|---|---|
| Molecular Weight | 257.26 g/mol |
| CAS Number | 61422-45-5 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | carmofur; 61422-45-5; Mifurol; HCFU; 1-Hexylcarbamoyl-5-fluorouracil |
| IUPAC/Chemical Name | 5-fluoro-N-hexyl-2,4-dioxopyrimidine-1-carboxamide |
| InChl Key | AOCCBINRVIKJHY-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C11H16FN3O3/c1-2-3-4-5-6-13-10(17)15-7-8(12)9(16)14-11(15)18/h7H,2-6H2,1H3,(H,13,17)(H,14,16,18) |
| References |
3D Conformer.
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