CARMUSTINE
Carmustine is an alkylating agent that crosslinks DNA and inhibits replication, used in brain tumors and lymphomas. Benefits include strong cytotoxicity and CNS penetration. Side effects include myelosuppression, pulmonary toxicity, and nausea. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of action
Carmustine (BCNU) is a nitrosourea alkylating agent that produces DNA interstrand and intrastrand crosslinks through chloroethyl carbocation intermediates. It also carbamoylates proteins, inhibiting repair enzymes. These effects disrupt replication, transcription and cellcycle progression, causing apoptosis. Carmustine easily crosses the bloodbrain barrier due to high lipophilicity.
Benefits and advantages
Used in neurooncology research, glioma models, DNAalkylation pathway studies, apoptosissignalling research, proteincarbamoylation investigations and chemotherapeuticdrugresistance modelling.
Side effects and risks
Risks include severe myelosuppression, pulmonary fibrosis, hepatic toxicity, seizures, nausea and longterm risk of secondary malignancies. Handle with full cytotoxicagent containment.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C5H11Cl2N3O2 |
|---|---|
| Molecular Weight | 214.05 g/mol |
| CAS Number | 154-93-8 |
| Storage Condition | Carmustine powder must be refrigerated at 2 – 8 °C. Both the powder and its solutions must be protected from light. |
| Solubility | less than 1 mg/mL at 64 °F (NTP, 1992) |
| Purity | Purity information is available upon request (COA). |
| Synonym | carmustine; 154-93-8; 1,3-Bis(2-chloroethyl)-1-nitrosourea; BCNU; Carmustin |
| IUPAC/Chemical Name | 1,3-bis(2-chloroethyl)-1-nitrosourea |
| InChl Key | DLGOEMSEDOSKAD-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C5H9Cl2N3O2/c6-1-3-8-5(11)10(9-12)4-2-7/h1-4H2,(H,8,11) |
| References |
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