About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of action
Carfilzomib is an irreversible proteasome inhibitor targeting the chymotrypsinlike activity of the 5 subunit of the 20S proteasome. It forms a covalent bond via its epoxyketone pharmacophore, blocking proteolytic degradation of ubiquitinated proteins. This leads to endoplasmicreticulum stress, impaired protein homeostasis, mitochondrial dysfunction and apoptosis in rapidly proliferating cells.
Benefits and advantages
Used in cancerbiology research, ubiquitinproteasome pathway studies, apoptosissignalling modelling, drugresistance mechanism analysis, multiplemyeloma models and proteostasis research. It serves as a reference irreversible proteasome inhibitor.
Side effects and risks
Risks include cardiotoxicity, hypertension, thrombocytopenia, neutropenia, infusion reactions, renal toxicity and peripheral neuropathy. Handle under full cytotoxicagent containment.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C40H57N5O7 |
|---|---|
| Molecular Weight | 719.9 g/mol |
| CAS Number | 868540-17-4 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Insoluble |
| Purity | Purity information is available upon request (COA). |
| Synonym | Carfilzomib; 868540-17-4; Kyprolis; PR-171; NSC-758252 |
| IUPAC/Chemical Name | (2S)-4-methyl-N-[(2S)-1-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]-4-phenylbutanoyl]amino]pentanamide |
| InChl Key | BLMPQMFVWMYDKT-NZTKNTHTSA-N |
| InChl Code | InChI=1S/C40H57N5O7/c1-27(2)22-32(36(47)40(5)26-52-40)42-39(50)34(24-30-14-10-7-11-15-30)44-38(49)33(23-28(3)4)43-37(48)31(17-16-29-12-8-6-9-13-29)41-35(46)25-45-18-20-51-21-19-45/h6-15,27-28,31-34H,16-26H2,1-5H3,(H,41,46)(H,42,50)(H,43,48)(H,44,49)/t31-,32-,33-,34-,40+/m0/s1 |
| References |
3D Conformer.
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