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Product Description
Mechanism of action
Carboplatin is a second-generation platinum-based chemotherapeutic that forms intra- and interstrand DNA crosslinks via aquated platinum complexes. These adducts distort DNA structure, block replication and transcription and trigger apoptosis via DNA-damage response pathways. Compared with cisplatin, carboplatin has more predictable pharmacokinetics and reduced nephrotoxicity due to its more stable leaving groups.
Benefits and advantages
Extensively used in oncology research, DNA-crosslinking studies, platinum-resistance mechanism investigations, apoptosis-pathway modelling, combination-chemotherapy experiments and comparative cisplatin–carboplatin SAR analysis. A core compound in solid-tumour research, especially ovarian and lung cancer models.
Side effects and risks
Risks include myelosuppression (especially thrombocytopenia), nausea, ototoxicity, nephrotoxicity at high exposure, hypersensitivity reactions and secondary malignancy risk. Requires full cytotoxic-agent containment, PPE and appropriate waste disposal.
Datasheet
| Molecular Formula | C6H12N2O4Pt |
|---|---|
| Molecular Weight | 371.25 g/mol |
| CAS Number | 41575-94-4 |
| Storage Condition | Intact vials should be stored at controlled room temperature & protected from light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | carboplatin; Paraplatin; 41575-94-4; Cbdca; Carboplatinum |
| IUPAC/Chemical Name | azane;cyclobutane-1,1-dicarboxylate;platinum(2+) |
| InChl Key | OLESAACUTLOWQZ-UHFFFAOYSA-L |
| InChl Code | InChI=1S/C6H8O4.2H3N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;+2/p-2 |
| References |
3D Conformer.
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