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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Digoxine (digoxin) is a classic cardiac glycoside that inhibits Na⁺/KATPase, increasing intracellular Ca²⁺ in cardiac tissue and producing positive inotropic effects. It also enhances vagal tone, reducing AVnode conduction. It is widely used in electrophysiology and heartfailure models.
Benefits and Advantages
Used in cardiac electrophysiology studies, Na⁺/KATPase pathway modelling, arrhythmia research, contractility assays and cardiomyocyte signalling investigations.
Side Effects and Risks
Risks include arrhythmias, digitalis toxicity, nausea, confusion, hyperkalemia or hypokalemia interactions, and narrow therapeutic margin. Handle with digitalisclass containment.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C41H64O14 |
|---|---|
| Molecular Weight | 780.9 g/mol |
| CAS Number | 20830-75-5 |
| Storage Condition | Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | digoxin; 20830-75-5; Lanoxin; Rougoxin; Digacin |
| IUPAC/Chemical Name | 3-[(3S,5R,8R,9S,10S,12R,13S,14S,17R)-3-[(2R,4S,5S,6R)-5-[(2S,4S,5S,6R)-5-[(2S,4S,5S,6R)-4,5-dihydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyloxan-2-yl]oxy-4-hydroxy-6-methyloxan-2-yl]oxy-12,14-dihydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one |
| InChl Key | LTMHDMANZUZIPE-PUGKRICDSA-N |
| InChl Code | InChI=1S/C41H64O14/c1-19-36(47)28(42)15-34(50-19)54-38-21(3)52-35(17-30(38)44)55-37-20(2)51-33(16-29(37)43)53-24-8-10-39(4)23(13-24)6-7-26-27(39)14-31(45)40(5)25(9-11-41(26,40)48)22-12-32(46)49-18-22/h12,19-21,23-31,33-38,42-45,47-48H,6-11,13-18H2,1-5H3/t19-,20-,21-,23-,24+,25-,26-,27+,28+,29+,30+,31-,33+,34+,35+,36-,37-,38-,39+,40+,41+/m1/s1 |
| References |
3D Conformer.
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