About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
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Product Description
Mechanism of action
Capsaicin is a vanilloid compound that activates transient receptor potential vanilloid‑1 (TRPV1) channels located on nociceptive C‑fibres. Activation opens non‑selective cation channels, causing calcium influx, neuron depolarisation and an initial burning sensation. Prolonged activation leads to functional desensitisation through depletion of substance P, reduced neuropeptide release, mitochondrial dysfunction in sensory terminals and reversible defunctionalisation of nociceptors. This dual‑phase mechanism makes capsaicin unique in pain‑pathway modulation.
Benefits and advantages
Used in pain‑neuroscience research, TRPV1‑channel studies, neuropathic‑pain modelling, neuropeptide‑release assays, sensory‑fiber desensitisation research, topical‑analgesic development and inflammatory‑pain pathway analysis. A reference TRPV1 agonist.
Side effects and risks
Risks include intense burning sensations, erythema, coughing (via TRPV1 activation in airways), neurotoxicity at very high exposure and mucosal irritation. Handle with strict dermal‑respiratory protective protocols.
Datasheet
| Molecular Formula | C18H27NO3 |
|---|---|
| Molecular Weight | 305.41 g/mol |
| CAS Number | 404-86-4 |
| Storage Condition | Store in a cool, dry place; protected from light |
| Solubility | Soluble in water |
| Purity | Purity information is available upon request (COA). |
| Synonym | N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide; 7553-53-9; DTXSID40859357; N-((4-hydroxy-3-methoxyphenyl)methyl)-8-methylnon-6-enamide; RefChem:1090695 |
| IUPAC/Chemical Name | (E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide |
| InChl Key | RZTKQEZTWDHRDP-VKHMYHEASA-N |
| InChl Code | InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21) |
| References | PubChem; ChemBL; FDA substance registry; |
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