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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of action
Bietaserpine is a rauwolfia-derived indole alkaloid structurally related to reserpine. It irreversibly inhibits vesicular monoamine transporter 2 (VMAT2), depleting presynaptic stores of serotonin, norepinephrine and dopamine. This blockade reduces sympathetic tone and central monoaminergic signalling.
Benefits and advantages
Used in autonomic-nervous-system research, catecholamine-depletion studies, depression-mechanism modelling, VMAT2 pathway investigation, and hypertension pharmacology. A reference agent for long-lasting monoamine depletion.
Side effects and risks
Risks include severe depression, sedation, hypotension, bradycardia, GI upset, and extrapyramidal symptoms. Handle with cytoactive and neuroactive compound safeguards.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C43H59N3O15 |
|---|---|
| Molecular Weight | 857.9 g/mol |
| CAS Number | 1111-44-0 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Bietaserpine bitartrate; TENSIBA; BIETASERPINE BITARTRATE [MI]; DL-152; 1-DIETHYLAMINOETHYLRESERPINE BITARTRATE |
| IUPAC/Chemical Name | (2R,3R)-2,3-dihydroxybutanedioic acid;methyl (1R,15S,17R,18R,19S,20S)-3-[2-(diethylamino)ethyl]-6,18-dimethoxy-17-(3,4,5-trimethoxybenzoyl)oxy-11,12,14,15,16,17,18,19,20,21-decahydro-1H-yohimban-19-carboxylate |
| InChl Key | BLAYNXSEESFUHR-XIVVIQKRSA-N |
| InChl Code | InChI=1S/C39H53N3O9.C4H6O6/c1-9-40(10-2)15-16-42-29-20-25(45-3)11-12-26(29)27-13-14-41-22-24-19-33(37(49-7)34(39(44)50-8)28(24)21-30(41)35(27)42)51-38(43)23-17-31(46-4)36(48-6)32(18-23)47-5;5-1(3(7)8)2(6)4(9)10/h11-12,17-18,20,24,28,30,33-34,37H,9-10,13-16,19,21-22H2,1-8H3;1-2,5-6H,(H,7,8)(H,9,10)/t24-,28+,30-,33-,34+,37+;1-,2-/m11/s1 |
| References |
3D Conformer.
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