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Product Description
Mechanism of Action
Corticosterone hemisuccinate is a water‑soluble ester of corticosterone used for improved delivery and controlled hydrolysis. After enzymatic cleavage, free corticosterone activates GR‑mediated transcription, suppresses inflammatory cascades and modulates metabolic homeostasis.
Benefits and Advantages
Used in soluble glucocorticoid‑delivery studies, stress‑hormone modulation research, inflammation models, and receptor‑activation kinetics experiments.
Side Effects and Risks
Risks include typical glucocorticoid effects: immunosuppression, adrenal inhibition, glucose elevation and behavioural changes. Handle as a steroid prodrug.
Datasheet
| Molecular Formula | C25H34O7 |
|---|---|
| Molecular Weight | 446.5 g/mol |
| CAS Number | 10215-77-7 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Corticosterone-21-hemisuccinate; 10215-77-7; Corticosterone hemisuccinate; IU50V885SP; Pregn-4-ene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11-hydroxy-, (11beta)- |
| IUPAC/Chemical Name | 4-[2-[(8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoic acid |
| InChl Key | KEECMXYFGNWLEA-BIGDRKAKSA-N |
| InChl Code | InChI=1S/C25H34O7/c1-24-10-9-15(26)11-14(24)3-4-16-17-5-6-18(25(17,2)12-19(27)23(16)24)20(28)13-32-22(31)8-7-21(29)30/h11,16-19,23,27H,3-10,12-13H2,1-2H3,(H,29,30)/t16-,17-,18+,19-,23+,24-,25-/m0/s1 |
| References |
3D Conformer.
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