About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Cortisone acetate is a prodrug converted by 11hydroxysteroid dehydrogenase type 1 (11HSD1) into active hydrocortisone. Its mechanism involves GRmediated suppression of proinflammatory transcription, inhibition of phospholipase A pathways, and modulation of glucose and lipid metabolism.
Benefits and Advantages
Used in glucocorticoidreceptor studies, inflammationsuppression modelling, HPAaxis function testing, endocrine pharmacology and metabolic disease research.
Side Effects and Risks
Risks include hyperglycemia, immunosuppression, adrenal feedback inhibition, fluid retention and mood alterations. Handle as a potent systemic glucocorticoid.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C23H30O6 |
|---|---|
| Molecular Weight | 402.5 g/mol |
| CAS Number | 50-04-4 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | CORTISONE ACETATE; Cortisone 21-acetate; 50-04-4; Cortone acetate; Cortisyl |
| IUPAC/Chemical Name | [2-[(8S,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-3,11-dioxo-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate |
| InChl Key | ITRJWOMZKQRYTA-RFZYENFJSA-N |
| InChl Code | InChI=1S/C23H30O6/c1-13(24)29-12-19(27)23(28)9-7-17-16-5-4-14-10-15(25)6-8-21(14,2)20(16)18(26)11-22(17,23)3/h10,16-17,20,28H,4-9,11-12H2,1-3H3/t16-,17-,20+,21-,22-,23-/m0/s1 |
| References |
3D Conformer.
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