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Product Description
Mechanism of Action
Ergostat is a trade name historically associated with ergotaminecontaining preparations used for migraine research. Ergotamine is a partial agonist at 5HTB/1D receptors and adrenergic receptors, producing cranial vasoconstriction and inhibition of neuropeptide release from trigeminal nerve endings.
Benefits and Advantages
Used in migrainepathophysiology studies, cranial vasculature tone modelling, 5HTB/1D receptor pharmacology, and neuropeptiderelease inhibition assays.
Side Effects and Risks
Risks include peripheral and coronary vasospasm, ischemia, nausea, paresthesias and serious ergotism with excessive or chronic dosing. Handle as a potent vasoconstrictive ergot preparation.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C70H76N10O16 |
|---|---|
| Molecular Weight | 1313.4 g/mol |
| CAS Number | 379-79-3 |
| Storage Condition | Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 – 8 °C. Hygroscopic. Light sensitive. Store under inert gas. /Ergotamine tartrate/ |
| Solubility | less than 1 mg/mL at 68 °F (NTP, 1992) |
| Purity | Purity information is available upon request (COA). |
| Synonym | ergotamine tartrate; Ergotamine D-tartrate; Lingraine; Wigrettes; Ergostat |
| IUPAC/Chemical Name | bis((6aR,9R)-N-[(1S,2S,4R,7S)-7-benzyl-2-hydroxy-4-methyl-5,8-dioxo-3-oxa-6,9-diazatricyclo[7.3.0.02,6]dodecan-4-yl]-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide);(2R,3R)-2,3-dihydroxybutanedioic acid |
| InChl Key | CJMJLDQKTOJACI-BGQAIRJTSA-N |
| InChl Code | InChI=1S/2C33H35N5O5.C4H6O6/c2*1-32(35-29(39)21-15-23-22-10-6-11-24-28(22)20(17-34-24)16-25(23)36(2)18-21)31(41)38-26(14-19-8-4-3-5-9-19)30(40)37-13-7-12-27(37)33(38,42)43-32;5-1(3(7)8)2(6)4(9)10/h2*3-6,8-11,15,17,21,25-27,34,42H,7,12-14,16,18H2,1-2H3,(H,35,39);1-2,5-6H,(H,7,8)(H,9,10)/t2*21-,25-,26+,27+,32-,33+;1-,2-/m111/s1 |
| References |
3D Conformer.
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