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Product Description
Mechanism of Action
Dosulepin (dothiepin) hydrochloride is a tricyclic antidepressant that inhibits reuptake of norepinephrine and serotonin while blocking muscarinic, histaminergic and α₁‑adrenergic receptors. It modulates monoamine signalling and improves mood, but carries notable cardiotoxicity risk.
Benefits and Advantages
Used in monoamine‑transporter research, antidepressant SAR studies, CNS receptor‑interaction assays, and chronic‑stress modelling.
Side Effects and Risks
Risks include cardiac arrhythmias, anticholinergic effects, seizures, sedation, weight gain and overdose toxicity. Handle with TCA‑class safety protocols.
Datasheet
| Molecular Formula | C19H21NS·HCl |
|---|---|
| Molecular Weight | 331.91 g/mol |
| CAS Number | 113-53-1 |
| Storage Condition | Store in a cool, dry place; protect from light |
| Solubility | Soluble in water |
| Purity | Purity information is available upon request (COA). |
| Synonym | Dothiepin; 113-53-1; DTXSID2022961; CHEBI:36798; RefChem:920635 |
| IUPAC/Chemical Name | Propan-1-amine, N,N-dimethyl-3-(6H-dibenzo[b,e]thiepin-11-ylidene) |
| InChl Key | Unavailable |
| InChl Code | Unavailable |
| References | PubChem; ChemBL; FDA; |
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