About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Didanosine (ddI) is a nucleoside reverse transcriptase inhibitor (NRTI) that is phosphorylated intracellularly to ddATP. ddATP competes with natural dATP and causes chain termination in viral DNA due to the absence of a 3’OH group. It effectively blocks HIV reverse transcriptase and inhibits viral replication.
Benefits and Advantages
Used in HIV polymerase research, chaintermination modelling, NRTI SAR studies, antiviralresistance assays, and nucleosidemetabolism research.
Side Effects and Risks
Risks include pancreatitis, peripheral neuropathy, lactic acidosis, hepatic toxicity, GI intolerance and mitochondrial toxicity. Handle with antiviralnucleoside precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C10H12N4O3 |
|---|---|
| Molecular Weight | 236.23 g/mol |
| CAS Number | 69655-05-6 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | 10 to 50 mg/mL at 70 °F (NTP, 1992) |
| Purity | Purity information is available upon request (COA). |
| Synonym | didanosine; 2',3'-Dideoxyinosine; 69655-05-6; DIDEOXYINOSINE; Videx |
| IUPAC/Chemical Name | 9-[(2R,5S)-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one |
| InChl Key | BXZVVICBKDXVGW-NKWVEPMBSA-N |
| InChl Code | InChI=1S/C10H12N4O3/c15-3-6-1-2-7(17-6)14-5-13-8-9(14)11-4-12-10(8)16/h4-7,15H,1-3H2,(H,11,12,16)/t6-,7+/m0/s1 |
| References |
3D Conformer.
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