DIENESTROL

Dienestrol is a synthetic estrogen used for menopausal symptoms and vaginal atrophy. Side effects include nausea, breast tenderness, and increased thrombotic risk. Only GMP materials will be supplied, logistics all according to GDP.

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Product Description


Mechanism of Action

Dienestrol is a synthetic nonsteroidal estrogen (stilbene class) that binds estrogen receptors ER and ER, activating estrogenresponsive gene transcription. It mimics endogenous estradiol and modulates reproductive and metabolic pathways.

Benefits and Advantages

Used in estrogenreceptor studies, endocrinesignalling research, hormoneresponsive gene assays, and reproductivebiology modelling.

Side Effects and Risks

Risks include thromboembolic reactions, endometrial hyperplasia, breast tenderness, fluid retention and nausea. Handle with hormonemodulating precautions.

Only GMP materials will be supplied, logistics all according to GDP.

Datasheet


Molecular Formula

C18H18O2

Molecular Weight

266.3 g/mol

CAS Number

84-17-3

Storage Condition

Commercially available dienestrol vaginal cream should be stored at a temperature less than 40 °C, preferably between 15-30 °C; freezing should be avoided.

Solubility

1.23e-02 g/L

Purity

Purity information is available upon request (COA).

Synonym

dienestrol; Dienoestrol; Dehydrostilbestrol; Cycladiene; Dienol

IUPAC/Chemical Name

4-[(2E,4E)-4-(4-hydroxyphenyl)hexa-2,4-dien-3-yl]phenol

InChl Key

NFDFQCUYFHCNBW-SCGPFSFSSA-N

InChl Code

InChI=1S/C18H18O2/c1-3-17(13-5-9-15(19)10-6-13)18(4-2)14-7-11-16(20)12-8-14/h3-12,19-20H,1-2H3/b17-3+,18-4+

References

https://pubchem.ncbi.nlm.nih.gov/compound/667476;

3D Conformer.

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