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Product Description
Mechanism of Action
Clobutinol is a centrally acting non‑opioid antitussive. It modulates the cough centre in the medulla oblongata by reducing neural excitability, likely through sodium‑channel modulation and central reflex suppression. It has no significant opioid‑receptor activity.
Benefits and Advantages
Used in cough‑reflex pathway research, medullary‑neurotransmission studies, antitussive mechanism comparisons and non‑opioid CNS‑modulator assays.
Side Effects and Risks
Risks include cardiac arrhythmias (QT prolongation), dizziness, CNS depression and hypersensitivity. Handle with caution due to cardiotoxic potential.
Datasheet
| Molecular Formula | C14H20ClNO |
|---|---|
| Molecular Weight | 255.78 g/mol |
| CAS Number | 14860-49-2 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Clobutinol; 14860-49-2; Clobutinolum; Iversal; 1-(4-chlorophenyl)-4-(dimethylamino)-2,3-dimethylbutan-2-ol |
| IUPAC/Chemical Name | 1-(4-chlorophenyl)-4-(dimethylamino)-2,3-dimethylbutan-2-ol |
| InChl Key | KVHHQGIIZCJATJ-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C14H22ClNO/c1-11(10-16(3)4)14(2,17)9-12-5-7-13(15)8-6-12/h5-8,11,17H,9-10H2,1-4H3 |
| References |
3D Conformer.
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