About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of action
Basiliximab is a chimeric monoclonal antibody (IgG1) that selectively targets the interleukin2 receptor chain (CD25) expressed on activated Tlymphocytes. By binding CD25, basiliximab blocks IL2mediated clonal expansion of Tcells, preventing progression of the cellular immune response. As CD25 is upregulated only after Tcell activation, basiliximab exhibits functional selectivity without widespread immunosuppression.
Benefits and advantages
Basiliximab is central in research on Tcell activation, transplant immunology, cytokine signalling, graft rejection, and immunomodulator design. Its high receptor specificity allows precise modelling of IL2driven lymphocyte proliferation and CD25targeted therapies. Useful in toleranceinduction studies and comparison of biologic vs smallmolecule immunosuppressants.
Side effects and risks
Potential risks include hypersensitivity, infection susceptibility, lymphopenia, gastrointestinal disturbances and rare anaphylactoid reactions. As a monoclonal antibody, it must be handled under biologicalagent containment with protection from temperature fluctuations and contamination.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Weight | g/mol |
|---|---|
| CAS Number | 179045-86-4 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| IUPAC/Chemical Name | N/A chimeric monoclonal antibody |
| References |
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