About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of action
Baclofen is a selective agonist of the GABAB metabotropic receptor. Activation of presynaptic GABAB receptors inhibits voltagegated calcium channels, reducing excitatory neurotransmitter release, while postsynaptic activation opens inwardly rectifying potassium channels, hyperpolarising neurons. These effects diminish spasticity by suppressing monosynaptic and polysynaptic spinal reflexes.
Benefits and advantages
Fundamental in neuropharmacology for studying Gproteincoupled inhibitory signalling, spinal motorneuron control, muscletone regulation, addiction pathways and central inhibitory network mapping. Also used in painmodulation models and receptorbinding kinetics research.
Side effects and risks
Risks include sedation, hypotonia, respiratory depression, seizures upon abrupt withdrawal and CNS depression. Laboratory exposure must be controlled strictly due to its potent neuromodulatory effects.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C10H12ClNO2 |
|---|---|
| Molecular Weight | 213.66 g/mol |
| CAS Number | 1134-47-0 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | less than 1 mg/mL at 64 °F (NTP, 1992) |
| Purity | Purity information is available upon request (COA). |
| Synonym | baclofen; 1134-47-0; Lioresal; 4-Amino-3-(4-chlorophenyl)butanoic acid; Baclon |
| IUPAC/Chemical Name | 4-amino-3-(4-chlorophenyl)butanoic acid |
| InChl Key | KPYSYYIEGFHWSV-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14) |
| References |
3D Conformer.
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