About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of action
Balsalazide is a prodrug consisting of mesalazine (5aminosalicylic acid, 5ASA) linked via an azo bond to an inert carrier molecule. Colonic bacterial azoreducing enzymes cleave this bond, releasing active 5ASA in the large intestine. 5ASA inhibits cyclooxygenase and lipoxygenase pathways, reduces prostaglandin and leukotriene production, and modulates inflammatory cytokines.
Benefits and advantages
Used extensively in gastrointestinal inflammation research, microbiotamediated prodrug activation studies, colonicdelivery system design, and inflammatorypathway mapping in ulcerativecolitis models. Its targeted release profile provides high specificity for the colonic lumen.
Side effects and risks
Possible risks include headache, abdominal discomfort, hypersensitivity, nephrotoxicity and rare blood disorders. Careful handling and protection from moisture are required.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C17H13N3O6 |
|---|---|
| Molecular Weight | 357.32 g/mol |
| CAS Number | 80573-04-2 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | DTXSID50861027; 5-((4-((2-carboxyethyl)carbamoyl)phenyl)diazenyl)-2-hydroxybenzoic acid; 5-({4-[(2-Carboxyethyl)carbamoyl]phenyl}diazenyl)-2-hydroxybenzoic acid; RefChem:1072307; DTXCID10810339 |
| IUPAC/Chemical Name | 5-[[4-(2-carboxyethylcarbamoyl)phenyl]diazenyl]-2-hydroxybenzoic acid |
| InChl Key | IPOKCKJONYRRHP-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C17H15N3O6/c21-14-6-5-12(9-13(14)17(25)26)20-19-11-3-1-10(2-4-11)16(24)18-8-7-15(22)23/h1-6,9,21H,7-8H2,(H,18,24)(H,22,23)(H,25,26) |
| References |
3D Conformer.
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