CLASCOTERONE
Clascoterone is a topical androgen receptor inhibitor used in dermatological and acne-related pharmaceutical research. It competes with androgens such as DHT at skin androgen receptors and can reduce sebaceous-gland signalling. Possible risks include local irritation, redness, dryness, itching and application-site reactions. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of Action
Clascoterone is a topical androgen receptor inhibitor. It competes with endogenous androgens such as dihydrotestosterone at androgen receptors in the skin, thereby reducing androgen-driven signalling in sebaceous glands and related inflammatory pathways.
Benefits and Advantages
Clascoterone is relevant for dermatological formulation development, acne-related research, sebocyte biology and local anti-androgen pharmacology. Its topical mode of action supports investigation of skin-targeted receptor modulation with limited systemic exposure when appropriately formulated.
Side Effects and Risks
Potential risks include local skin irritation, erythema, dryness, pruritus and application-site reactions. Because it modulates androgen receptor signalling, endocrine-related effects must be evaluated during development and use should remain within qualified pharmaceutical and regulatory frameworks.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C24H34O5 |
|---|---|
| Molecular Weight | 402.53 g/mol |
| CAS Number | 19608-29-8 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Clascoterone; CB-03-01; CB-0301; Cortexolone 17-alpha-propionate; Winlevi |
| IUPAC/Chemical Name | [(8R,9S,10R,13S,14S,17R)-17-(2-hydroxyacetyl)-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] propanoate |
| InChl Key | GPNHMOZDMYNCPO-PDUMRIMRSA-N |
| InChl Code | InChI=1S/C24H34O5/c1-4-21(28)29-24(20(27)14-25)12-9-19-17-6-5-15-13-16(26)7-10-22(15,2)18(17)8-11-23(19,24)3/h13,17-19,25H,4-12,14H2,1-3H3/t17-,18+,19+,22+,23+,24+/m1/s1 |
| References | https://pubchem.ncbi.nlm.nih.gov/compound/11750009; small-molecule |
3D Conformer.
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