GS441524
GS-441524 is a nucleoside analogue related to remdesivir and is used in antiviral and RNA-virus replication research. After intracellular phosphorylation it can form an active triphosphate that interferes with viral RNA polymerase activity in experimental systems. Risks include off-target cellular effects and unknown safety margins outside controlled research. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of Action
GS-441524 is a nucleoside analogue and the parent nucleoside related to remdesivir. After intracellular phosphorylation to the active triphosphate form, it can interfere with viral RNA-dependent RNA polymerase activity and disrupt replication of susceptible RNA viruses in experimental systems.
Benefits and Advantages
GS-441524 is used in antiviral research, nucleoside analogue screening, metabolite comparison and studies of intracellular activation pathways. It is especially relevant in controlled investigations where compound stability, phosphorylation efficiency and polymerase interaction are evaluated.
Side Effects and Risks
Risks depend on exposure level, formulation and biological system. Potential concerns include off-target cellular effects, mitochondrial or replication-related toxicity, assay interference and unknown safety margins outside validated research settings. Use should be restricted to qualified laboratory or pharmaceutical development environments.
Professional use only. Supplied exclusively for qualified pharmaceutical, analytical or laboratory environments.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C12H13N5O4 |
|---|---|
| Molecular Weight | 291.26 g/mol |
| CAS Number | 1191237-69-0 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Soluble in DMSO and DMF; solubility depends on solvent and conditions. |
| Purity | Purity information is available upon request (COA). |
| Synonym | GS-441524; GS441524; Remdesivir metabolite; 1BQK176DT6 |
| IUPAC/Chemical Name | (2R,3R,4S,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbonitrile |
| InChl Key | BRDWIEOJOWJCLU-LTGWCKQJSA-N |
| InChl Code | InChI=1S/C12H13N5O4/c13-4-12(10(20)9(19)7(3-18)21-12)8-2-1-6-11(14)15-5-16-17(6)8/h1-2,5,7,9-10,18-20H,3H2,(H2,14,15,16)/t7-,9-,10-,12+/m1/s1 |
| References | https://pubchem.ncbi.nlm.nih.gov/compound/44468216; small-molecule |
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