RESINIFERATOXINE
Resiniferatoxin is an ultrapotent TRPV1 receptor agonist used in advanced pain-pathway, nociception and vanilloid receptor research. It can induce strong calcium influx and desensitisation of TRPV1-positive sensory neurons. The compound is highly irritating and potentially neurotoxic, requiring strict professional handling. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of Action
Resiniferatoxin is an ultrapotent vanilloid compound that activates the TRPV1 receptor, a non-selective cation channel expressed on nociceptive sensory neurons. Strong TRPV1 activation can cause calcium influx, neuronal desensitisation and, at high exposure, functional ablation of TRPV1-positive fibres.
Benefits and Advantages
The compound is used in advanced pain-pathway research, TRPV1 pharmacology, sensory-neuron selectivity studies and comparative evaluation of vanilloid receptor agonists. Its high potency makes it useful where precise receptor-driven models are required, but it also demands strict control of concentration and exposure.
Side Effects and Risks
Resiniferatoxin is highly irritating and extremely potent. Exposure may cause severe burning sensation, neurotoxicity, inflammation or tissue injury depending on route and dose. It must be handled only by trained professionals with suitable containment, protective equipment and validated disposal procedures.
Professional use only. Supplied exclusively for qualified pharmaceutical, analytical or laboratory environments.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C37H40O9 |
|---|---|
| Molecular Weight | 628.71 g/mol |
| CAS Number | 57444-62-9 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Soluble in organic solvents such as DMSO and ethanol; limited aqueous solubility. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Resiniferatoxin; RTX; RTX-107; Euphorbium resiniferatoxin |
| IUPAC/Chemical Name | [(1R,2R,6R,10S,11R,13S,15R,17R)-13-benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-prop-1-en-2-yl-12,14,18-trioxapentacyclo[11.4.1.01,10.02,6.011,15]octadeca-3,8-dien-8-yl]methyl 2-(4-hydroxy-3-methoxyphenyl)acetate |
| InChl Key | DSDNAKHZNJAGHN-MXTYGGKSSA-N |
| InChl Code | InChI=1S/C37H40O9/c1-21(2)35-17-23(4)37-27(33(35)44-36(45-35,46-37)19-24-9-7-6-8-10-24)14-26(18-34(41)30(37)13-22(3)32(34)40)20-43-31(39)16-25-11-12-28(38)29(15-25)42-5/h6-15,23,27,30,33,38,41H,1,16-20H2,2-5H3/t23-,27+,30-,33-,34-,35-,36-,37-/m1/s1 |
| References | https://pubchem.ncbi.nlm.nih.gov/compound/5702546; small-molecule |
3D Conformer.
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