About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Furosemide is a loop diuretic that inhibits the NaK2Cl cotransporter (NKCC2) in the thick ascending limb of Henles loop, reducing reabsorption of sodium, chloride and potassium. This markedly increases diuresis and natriuresis, reduces extracellular fluid volume and lowers venous pressures.
Benefits and Advantages
Used in renalphysiology modelling, electrolytetransport research, edema and heartfailure studies and NKCC2 inhibition assays.
Side Effects and Risks
Risks include hypokalemia, hyponatremia, dehydration, ototoxicity (high doses), hypotension and metabolic alkalosis. Handle with diureticclass precautions and electrolytemonitoring awareness.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C12H11ClN2O5S |
|---|---|
| Molecular Weight | 330.74 g/mol |
| CAS Number | 54-31-9 |
| Storage Condition | Keep container tightly closed in a dry and well-ventilated place. |
| Solubility | less than 1 mg/mL at 73 °F (NTP, 1992) |
| Purity | Purity information is available upon request (COA). |
| Synonym | furosemide; 54-31-9; Frusemide; Lasix; Furanthril |
| IUPAC/Chemical Name | 4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid |
| InChl Key | ZZUFCTLCJUWOSV-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19) |
| References |
3D Conformer.
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