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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Product Description
Mechanism of Action
Furosemide is a loop diuretic that inhibits the Na⁺‑K⁺‑2Cl⁻ cotransporter (NKCC2) in the thick ascending limb of Henle’s loop, reducing reabsorption of sodium, chloride and potassium. This markedly increases diuresis and natriuresis, reduces extracellular fluid volume and lowers venous pressures.
Benefits and Advantages
Used in renal‑physiology modelling, electrolyte‑transport research, edema and heart‑failure studies and NKCC2 inhibition assays.
Side Effects and Risks
Risks include hypokalemia, hyponatremia, dehydration, ototoxicity (high doses), hypotension and metabolic alkalosis. Handle with diuretic‑class precautions and electrolyte‑monitoring awareness.
Datasheet
| Molecular Formula | C12H11ClN2O5S |
|---|---|
| Molecular Weight | 330.74 g/mol |
| CAS Number | 54-31-9 |
| Storage Condition | Keep container tightly closed in a dry and well-ventilated place. |
| Solubility | less than 1 mg/mL at 73 °F (NTP, 1992) |
| Purity | Purity information is available upon request (COA). |
| Synonym | furosemide; 54-31-9; Frusemide; Lasix; Furanthril |
| IUPAC/Chemical Name | 4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid |
| InChl Key | ZZUFCTLCJUWOSV-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C12H11ClN2O5S/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h1-5,15H,6H2,(H,16,17)(H2,14,18,19) |
| References |
3D Conformer.
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