About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Fumagillin is a complex sesquiterpene antibiotic that irreversibly inhibits methionine aminopeptidase2 (MetAP2), an enzyme involved in cotranslational processing of nascent proteins and regulation of endothelialcell proliferation. By covalently binding MetAP2, fumagillin suppresses angiogenesis and alters cellular growth and differentiation pathways.
Benefits and Advantages
Used in angiogenesisinhibition research, MetAP2target validation, endothelialcell signalling studies, antiparasitic investigations (e.g. microsporidia), and structureactivity relationship work on fumagillin analogues.
Side Effects and Risks
Risks include neurotoxicity, GI upset, hepatotoxicity and bonemarrow suppression at high or prolonged exposure. Handle with potent enzymeinhibitor and cytotoxiccompound precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C26H34O7 |
|---|---|
| Molecular Weight | 458.5 g/mol |
| CAS Number | 23110-15-8 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | fumagillin; 23110-15-8; Fugillin; Fumidil; Fumagilina |
| IUPAC/Chemical Name | (2E,4E,6E,8E)-10-[[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl]oxy]-10-oxodeca-2,4,6,8-tetraenoic acid |
| InChl Key | NGGMYCMLYOUNGM-CSDLUJIJSA-N |
| InChl Code | InChI=1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+/t19-,20-,23-,24-,25+,26+/m1/s1 |
| References |
3D Conformer.
(Click, turn or enlarge)
Download our GMP API Product List.
MedicaPharma is an EU-based supplier of GMP-certified APIs that serves leading healthcare institutions and research organizations.
Click here to download our full API product list.
