FULVESTRANT
Fulvestrant is an estrogen receptor antagonist used in hormonepositive breast cancer. Side effects include injectionsite pain, nausea, and fatigue. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of Action
Fulvestrant is a selective estrogen receptor degrader (SERD) that binds ER, accelerates receptor degradation and blocks estrogenmediated transcription.
Benefits and Advantages
Used in endocrinetherapy models, ER degradation assays, breastcancer signalling research and SERD SAR analysis.
Side Effects and Risks
Injectionsite pain, hot flashes, nausea and hepatic changes.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C32H47F5O3S |
|---|---|
| Molecular Weight | 606.8 g/mol |
| CAS Number | 129453-61-8 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Fulvestrant; 129453-61-8; Faslodex; Ici 182780; ICI-182780 |
| IUPAC/Chemical Name | (7R,8R,9S,13S,14S,17S)-13-methyl-7-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol |
| InChl Key | VWUXBMIQPBEWFH-WCCTWKNTSA-N |
| InChl Code | InChI=1S/C32H47F5O3S/c1-30-17-15-26-25-12-11-24(38)21-23(25)20-22(29(26)27(30)13-14-28(30)39)10-7-5-3-2-4-6-8-18-41(40)19-9-16-31(33,34)32(35,36)37/h11-12,21-22,26-29,38-39H,2-10,13-20H2,1H3/t22-,26-,27+,28+,29-,30+,41?/m1/s1 |
| References |
3D Conformer.
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