DELAVIRDINE
Delstrigo is a fixed‑dose combination of doravirine, lamivudine, and tenofovir disoproxil fumarate used in HIV‑1 infection. It combines NNRTI and NRTI mechanisms to suppress viral replication. Benefits include once‑daily dosing and a favorable lipid profile. Side effects include nausea, headache, fatigue, and rare hepatic effects.
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Product Description
Mechanism of Action
Delavirdine is a non‑nucleoside reverse transcriptase inhibitor (NNRTI) that binds an allosteric pocket of HIV‑1 reverse transcriptase. This non‑competitive inhibition disrupts DNA polymerization, halting viral replication. It shows rapid resistance emergence, making it useful mainly in mechanistic and resistance‑mutation studies.
Benefits and Advantages
Used in HIV‑1 RT allosteric modelling, antiviral‑mechanism research, NNRTI‑resistance mutation assays, polymerase‑inhibition studies and antiviral‑drug SAR.
Side Effects and Risks
Risks include rash, hepatotoxicity, GI upset, drug–drug interactions via CYP3A4 inhibition and hypersensitivity reactions. Handle with antiviral‑compound precautions.
Datasheet
| Molecular Formula | C22H28N6O3S |
|---|---|
| Molecular Weight | 456.6 g/mol |
| CAS Number | 136817-59-9 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | 8.60e-02 g/L |
| Purity | Purity information is available upon request (COA). |
| Synonym | Delavirdine; 136817-59-9; U 90152; Delavirdina; DOL5F9JD3E |
| IUPAC/Chemical Name | N-[2-[4-[3-(propan-2-ylamino)-2-pyridinyl]piperazine-1-carbonyl]-1H-indol-5-yl]methanesulfonamide |
| InChl Key | WHBIGIKBNXZKFE-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C22H28N6O3S/c1-15(2)24-19-5-4-8-23-21(19)27-9-11-28(12-10-27)22(29)20-14-16-13-17(26-32(3,30)31)6-7-18(16)25-20/h4-8,13-15,24-26H,9-12H2,1-3H3 |
| References |
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