DENOPAMINE
Demecarium chloride is a related cholinesterase inhibitor with similar ocular hypotensive effects. It prolongs the action of endogenous acetylcholine in the eye. Side effects include irritation, increased tearing, and potential systemic cholinergic effects in susceptible patients.
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Product Description
Mechanism of Action
Denopamine is a selective β₁‑adrenergic receptor agonist with positive inotropic effects. It increases cardiac contractility and cardiac output with minimal chronotropic stimulation. Activation of β₁‑AR elevates cAMP, enhances Ca²⁺ cycling and improves myocardial efficiency.
Benefits and Advantages
Used in cardiac‑inotropy modelling, β‑adrenergic signalling research, heart‑failure physiology assays, cardiac cAMP‑pathway studies and pharmacodynamic modelling.
Side Effects and Risks
Risks include tachycardia, arrhythmias, angina, tremor, hypotension and CNS stimulation. Handle as a potent β‑agonist.
Datasheet
| Molecular Formula | C17H23NO2 |
|---|---|
| Molecular Weight | 317.4 g/mol |
| CAS Number | 71771-90-9 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Denopamine; 71771-90-9; Kalgut; Denopamina; Denopaminum |
| IUPAC/Chemical Name | 4-[(1R)-2-[2-(3,4-dimethoxyphenyl)ethylamino]-1-hydroxyethyl]phenol |
| InChl Key | VHSBBVZJABQOSG-INIZCTEOSA-N |
| InChl Code | InChI=1S/C18H23NO4/c1-22-17-8-3-13(11-18(17)23-2)9-10-19-12-16(21)14-4-6-15(20)7-5-14/h3-8,11,16,19-21H,9-10,12H2,1-2H3/t16-/m0/s1 |
| References |
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