DEFERIPRON
Deferoxamine mesylate is a parenteral iron chelator that binds ferric iron and promotes renal and biliary excretion. It is used in acute iron poisoning and chronic overload. Benefits include rapid reduction of free iron. Side effects include injection‑site reactions, visual and auditory disturbances, and hypotension with rapid infusion.
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Product Description
Mechanism of Action
Deferiprone is a bidentate iron‑chelating agent that binds Fe³⁺ with high affinity, forming a 3:1 drug‑to‑iron complex. It reduces toxic iron accumulation in tissues, prevents Fenton‑reaction‑driven oxidative damage, and modulates iron‑regulatory pathways at the cellular level.
Benefits and Advantages
Used in iron‑overload models, chelation‑therapy research, oxidative‑stress assays, iron‑transport studies and mitochondrial‑damage modelling.
Side Effects and Risks
Risks include agranulocytosis, neutropenia, arthralgia, gastrointestinal discomfort, zinc depletion and hepatic dysfunction. Handle with hematologic‑risk controls.
Datasheet
| Molecular Formula | C7H9NO2 |
|---|---|
| Molecular Weight | 139.15 g/mol |
| CAS Number | 30652-11-0 |
| Storage Condition | Store at 20 deg to 25 °C (68 deg to 77 °F); excursions permitted to 15 deg to 30 °C (59 deg to 86 °F). |
| Solubility | Maximum water solubility of 1618 g/L at 24° |
| Purity | Purity information is available upon request (COA). |
| Synonym | deferiprone; 30652-11-0; 3-Hydroxy-1,2-dimethyl-4(1H)-pyridone; Ferriprox; 3-hydroxy-1,2-dimethylpyridin-4(1H)-one |
| IUPAC/Chemical Name | 3-hydroxy-1,2-dimethylpyridin-4-one |
| InChl Key | TZXKOCQBRNJULO-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C7H9NO2/c1-5-7(10)6(9)3-4-8(5)2/h3-4,10H,1-2H3 |
| References |
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