DEFACTINIB
Deferiprone is an oral bidentate iron chelator used to treat transfusional iron overload, especially in thalassemia patients. It promotes urinary iron excretion. Benefits include effective myocardial iron removal. Side effects include neutropenia, agranulocytosis, arthralgia, and gastrointestinal upset, requiring frequent blood count monitoring. Only GMP materials will be supplied, logistics all according to GDP.
About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Defactinib is a selective inhibitor of focal adhesion kinase (FAK) and prolinerich tyrosine kinase 2 (PYK2). By blocking FAK/PYK2 autophosphorylation, it disrupts tumourcell adhesion, migration, invasion and survival, particularly in cancers with activated integrin signalling or mesenchymal phenotypes.
Benefits and Advantages
Used in FAKpathway modelling, tumourmicroenvironment research, metastasis studies, integrinsignalling assays, and kinaseinhibitor SAR exploration.
Side Effects and Risks
Risks include fatigue, nausea, thrombocytopenia, hepatotoxicity and rare pneumonitis. Handle with targetedkinaseinhibitor precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C20H21F3N8O3S |
|---|---|
| Molecular Weight | 510.5 g/mol |
| CAS Number | 1073154-85-4 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Defactinib; 1073154-85-4; VS-6063; N-methyl-4-((4-(((3-(N-methylmethylsulfonamido)pyrazin-2-yl)methyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)benzamide; 53O87HA2QU |
| IUPAC/Chemical Name | N-methyl-4-[[4-[[3-[methyl(methylsulfonyl)amino]pyrazin-2-yl]methylamino]-5-(trifluoromethyl)pyrimidin-2-yl]amino]benzamide |
| InChl Key | FWLMVFUGMHIOAA-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C20H21F3N8O3S/c1-24-18(32)12-4-6-13(7-5-12)29-19-28-10-14(20(21,22)23)16(30-19)27-11-15-17(26-9-8-25-15)31(2)35(3,33)34/h4-10H,11H2,1-3H3,(H,24,32)(H2,27,28,29,30) |
| References |
3D Conformer.
(Click, turn or enlarge)
Download our GMP API Product List.
MedicaPharma is an EU-based supplier of GMP-certified APIs that serves leading healthcare institutions and research organizations.
Click here to download our full API product list.
