DENOSUMAB
Demetexine is an antitussive and mild bronchodilator used in respiratory conditions to reduce cough and ease breathing. Its action involves modulation of respiratory center sensitivity. Side effects may include drowsiness, dizziness, and gastrointestinal discomfort. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of Action
Denosumab is a fully human monoclonal antibody targeting RANKL (receptor activator of nuclear factor B ligand). By binding RANKL, it prevents activation of RANK on osteoclast precursors, suppressing osteoclast formation, function and survival. This reduces bone resorption and stabilizes skeletal structure.
Benefits and Advantages
Used in bonemetabolism research, osteoclastogenesis modelling, RANK/RANKL pathway studies, osteoporosis investigations, and monoclonalantibody mechanism analysis.
Side Effects and Risks
Risks include hypocalcemia, osteonecrosis of the jaw, atypical fractures, infections and dermatologic reactions. Handle with monoclonalbiologic containment procedures.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | Protein |
|---|---|
| Molecular Weight | 147000.0 g/mol |
| CAS Number | 615258-40-1 |
| Storage Condition | Store in a cool, dry place; protect from light |
| Solubility | Soluble in water |
| Purity | Purity information is available upon request (COA). |
| IUPAC/Chemical Name | Monoclonal IgG2 antibody |
| InChl Key | Unavailable |
| InChl Code | Unavailable |
| References | PubChem; ChemBL; FDA; |
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