DAUNORUBICIN
Dasatinib is a tyrosine kinase inhibitor targeting BCRABL and SRC family kinases. It is used in chronic myeloid leukemia and Ph+ acute lymphoblastic leukemia. Benefits include deep molecular responses and efficacy in imatinibresistant disease. Side effects include myelosuppression, pleural effusions, bleeding risk, and QT prolongation. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of Action
Daunorubicin is an anthracycline antineoplastic agent that intercalates between DNA base pairs, inhibiting nucleicacid synthesis. It potently inhibits topoisomerase II, preventing DNA unwinding and generating lethal doublestrand breaks. Additionally, it undergoes redox cycling to generate reactive oxygen species (ROS), contributing to mitochondrial damage and apoptotic signalling.
Benefits and Advantages
Used in leukemiamodel research, topoisomeraseII inhibition studies, ROSmediated cytotoxicity assays, multidrugresistance (Pgp/MDR1) modelling, apoptosis signalling experiments, and anthracycline SAR development.
Side Effects and Risks
Risks include cumulative cardiomyopathy, severe myelosuppression, mucositis, alopecia, hepatotoxicity, and tissue necrosis upon extravasation. Handle only under strict cytotoxicagent containment.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C27H29NO10 |
|---|---|
| Molecular Weight | 527.5 g/mol |
| CAS Number | 20830-81-3 |
| Storage Condition | PRECAUTIONS FOR "CARCINOGENS": Storage site should be as close as practical to lab in which carcinogens are to be used, so that only small quantities required for … expt need to be carried. Carcinogens should be kept in only one section of cupboard, an explosion-proof refrigerator or freezer (depending on chemicophysical properties …) that bears appropriate label. An inventory … should be kept, showing quantity of carcinogen & date it was acquired … Facilities for dispensing … should be contiguous to storage area. /Chemical Carcinogens/ |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | daunorubicin; Daunomycin; 20830-81-3; Rubidomycin; Acetyladriamycin |
| IUPAC/Chemical Name | (7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione |
| InChl Key | STQGQHZAVUOBTE-VGBVRHCVSA-N |
| InChl Code | InChI=1S/C27H29NO10/c1-10-22(30)14(28)7-17(37-10)38-16-9-27(35,11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33/h4-6,10,14,16-17,22,30,32,34-35H,7-9,28H2,1-3H3/t10-,14-,16-,17-,22+,27-/m0/s1 |
| References |
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