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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
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Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Chloroquanil is a dihydrofolate reductase (DHFR) inhibitor belonging to the antifolate class. It disrupts folate recycling, preventing synthesis of thymidylate and purines required for DNA replication. It selectively targets protozoal DHFR, making it effective in antimalarial research.
Benefits and Advantages
Used in malaria‑pathway models, protozoal folate‑cycle research, DHFR‑inhibitor SAR investigations, resistance‑mutation mapping and combination‑therapy optimisation with synergistic antifolates.
Side Effects and Risks
Risks include hepatotoxicity, bone‑marrow suppression, GI disturbances and hypersensitivity. Handle with antifolate‑compound precautions.
Datasheet
| Molecular Formula | C11H17Cl2N5 |
|---|---|
| Molecular Weight | 290.19 g/mol |
| CAS Number | 637-32-1 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Proguanil hydrochloride; Chloroguanide hydrochloride; 637-32-1; Chlorguanide hydrochloride; Paludrine |
| IUPAC/Chemical Name | (1E)-1-[amino-(4-chloroanilino)methylidene]-2-propan-2-ylguanidine;hydrochloride |
| InChl Key | SARMGXPVOFNNNG-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C11H16ClN5.ClH/c1-7(2)15-10(13)17-11(14)16-9-5-3-8(12)4-6-9;/h3-7H,1-2H3,(H5,13,14,15,16,17);1H |
| References |
3D Conformer.
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