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Product Description
Mechanism of action
Carmofur is a lipophilic fluoropyrimidine derivative and prodrug of 5‑fluorouracil (5‑FU). It inhibits thymidylate synthase, depleting dTMP required for DNA synthesis, and incorporates into RNA to disrupt transcription. Carmofur also inhibits acid ceramidase, accumulating ceramide and inducing apoptosis through sphingolipid‑mediated pathways.
Benefits and advantages
Used in anticancer research, fluoropyrimidine‑pathway studies, thymidylate‑synthase inhibition assays, sphingolipid‑signalling research, apoptosis modelling, colorectal‑cancer studies and chemoresistance analysis.
Side effects and risks
Risks include myelosuppression, diarrhoea, mucositis, hepatotoxicity, neurotoxicity and dermatologic reactions. Handle with cytotoxic‑compound containment.
Datasheet
| Molecular Formula | C11H15FN2O3 |
|---|---|
| Molecular Weight | 257.26 g/mol |
| CAS Number | 61422-45-5 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | carmofur; 61422-45-5; Mifurol; HCFU; 1-Hexylcarbamoyl-5-fluorouracil |
| IUPAC/Chemical Name | 5-fluoro-N-hexyl-2,4-dioxopyrimidine-1-carboxamide |
| InChl Key | AOCCBINRVIKJHY-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C11H16FN3O3/c1-2-3-4-5-6-13-10(17)15-7-8(12)9(16)14-11(15)18/h7H,2-6H2,1H3,(H,13,17)(H,14,16,18) |
| References |
3D Conformer.
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