About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of action
Capsaicin is a vanilloid compound that activates transient receptor potential vanilloid1 (TRPV1) channels located on nociceptive Cfibres. Activation opens nonselective cation channels, causing calcium influx, neuron depolarisation and an initial burning sensation. Prolonged activation leads to functional desensitisation through depletion of substance P, reduced neuropeptide release, mitochondrial dysfunction in sensory terminals and reversible defunctionalisation of nociceptors. This dualphase mechanism makes capsaicin unique in painpathway modulation.
Benefits and advantages
Used in painneuroscience research, TRPV1channel studies, neuropathicpain modelling, neuropeptiderelease assays, sensoryfiber desensitisation research, topicalanalgesic development and inflammatorypain pathway analysis. A reference TRPV1 agonist.
Side effects and risks
Risks include intense burning sensations, erythema, coughing (via TRPV1 activation in airways), neurotoxicity at very high exposure and mucosal irritation. Handle with strict dermalrespiratory protective protocols.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C18H27NO3 |
|---|---|
| Molecular Weight | 305.41 g/mol |
| CAS Number | 404-86-4 |
| Storage Condition | Store in a cool, dry place; protected from light |
| Solubility | Soluble in water |
| Purity | Purity information is available upon request (COA). |
| Synonym | N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide; 7553-53-9; DTXSID40859357; N-((4-hydroxy-3-methoxyphenyl)methyl)-8-methylnon-6-enamide; RefChem:1090695 |
| IUPAC/Chemical Name | (E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methylnon-6-enamide |
| InChl Key | RZTKQEZTWDHRDP-VKHMYHEASA-N |
| InChl Code | InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21) |
| References | PubChem; ChemBL; FDA substance registry; |
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