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Product Description
Mechanism of action
Azosemide is a loop diuretic that inhibits the NaK2Cl cotransporter (NKCC2) in the thick ascending limb of the loop of Henle. This reduces sodium and chloride reabsorption, leading to increased diuresis and natriuresis. It has longer duration and lower risk of ototoxicity compared with some other loop diuretics.
Benefits and advantages
Used in renal physiology research, transporter kinetics (NKCC2), diuretic SAR optimisation and models of fluid overload and electrolyte regulation. Also relevant in cardiovascularrenal interaction studies.
Side effects and risks
Risks include electrolyte disturbances (hyponatraemia, hypokalaemia), dehydration, hypotension and renal function changes. Handle with diureticactive safety controls.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C17H13ClN2O4S |
|---|---|
| Molecular Weight | 370.8 g/mol |
| CAS Number | 27589-33-9 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | azosemide; 27589-33-9; Azosemid; Diart; Azosemida |
| IUPAC/Chemical Name | 2-chloro-5-(2H-tetrazol-5-yl)-4-(thiophen-2-ylmethylamino)benzenesulfonamide |
| InChl Key | HMEDEBAJARCKCT-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C12H11ClN6O2S2/c13-9-5-10(15-6-7-2-1-3-22-7)8(12-16-18-19-17-12)4-11(9)23(14,20)21/h1-5,15H,6H2,(H2,14,20,21)(H,16,17,18,19) |
| References |
3D Conformer.
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