ADALIMUMAB
Adalimumab is a monoclonal antibody targeting tumor necrosis factor-alpha (TNF), reducing inflammation in autoimmune diseases such as rheumatoid arthritis, Crohns disease, and psoriasis. Benefits include significant symptom improvement and disease-modifying effects. Risks involve increased susceptibility to infections, injection-site reactions, headache, and rare immune-related events, requiring regular clinical monitoring. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of action
Adalimumab is a fully human monoclonal IgG1 antibody directed against tumour necrosis factor alpha (TNF). By binding with high affinity to soluble and membranebound TNF, it prevents interaction with TNF receptors and inhibits downstream proinflammatory signalling cascades.
Benefits and advantages
Adalimumab is a key biologic diseasemodifying antirheumatic drug (bDMARD) used in rheumatoid arthritis, psoriasis, inflammatory bowel disease and other immunemediated inflammatory disorders. It offers targeted modulation of a central cytokine in inflammation, with wellestablished efficacy and a broad range of approved indications.
Side effects and risks
TNF inhibition increases susceptibility to infections, including tuberculosis and opportunistic pathogens. Other adverse effects include injectionsite reactions, hypersensitivity, demyelinating events, heart failure exacerbation and a possible increased risk of malignancies with longterm use. Manufacturing and handling require stringent biologicsgrade quality systems.
Professional use only. Supplied exclusively to licensed manufacturers and healthcare institutions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C20H22N2O7S |
|---|---|
| Molecular Weight | 434.5 g/mol |
| CAS Number | 127373-66-4 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Sivelestat; 127373-66-4; Ono-5046; 2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetic acid; LY544349 |
| IUPAC/Chemical Name | 2-[[2-[[4-(2,2-dimethylpropanoyloxy)phenyl]sulfonylamino]benzoyl]amino]acetic acid |
| InChl Key | BTGNGJJLZOIYID-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C20H22N2O7S/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24) |
| References |
3D Conformer.
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