ACYCLOGUANOSINE
Acycloguanosine (acyclovir) is an antiviral nucleoside analogue that inhibits viral DNA polymerase, leading to chain termination during replication. It is widely used for herpesvirus infections. Benefits include high selectivity for infected cells and strong safety profile. Side effects are generally mild, including nausea, headache, and fatigue, though renal toxicity may occur at high doses or in dehydrated patients.
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Product Description
Mechanism of action
Acycloguanosine (acyclovir) is a guanine nucleoside analogue with selective antiviral activity against herpes viruses. After phosphorylation by viral thymidine kinase and subsequent host enzymes, acyclovir triphosphate competitively inhibits viral DNA polymerase and acts as a chain terminator upon incorporation into viral DNA.
Benefits and advantages
Acyclovir is widely used in the treatment and prophylaxis of herpes simplex and varicella‑zoster infections. Its selective activation in virus‑infected cells provides a favourable therapeutic index, and multiple dosage forms (oral, topical, intravenous) allow flexible clinical use.
Side effects and risks
Generally well tolerated, acyclovir can cause gastrointestinal upset, headache and, at high intravenous doses or in predisposed patients, nephrotoxicity due to crystallisation in renal tubules. Adequate hydration and dose adjustment in renal impairment reduce risk. The API should be handled with standard precautions for antiviral agents.
Professional use only. Supplied exclusively to licensed pharmaceutical manufacturers and institutions.
Datasheet
| Molecular Formula | C8H11N5O3 |
|---|---|
| Molecular Weight | 225.20 g/mol |
| CAS Number | 59277-89-3 |
| Storage Condition | Keep container tightly closed in a dry and well-ventilated place. |
| Solubility | 1.41mg/mL at 25°C |
| Purity | Purity information is available upon request (COA). |
| Synonym | acyclovir; 59277-89-3; Aciclovir; Acycloguanosine; Virorax |
| IUPAC/Chemical Name | 2-amino-9-(2-hydroxyethoxymethyl)-1H-purin-6-one |
| InChl Key | MKUXAQIIEYXACX-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15) |
| References |
3D Conformer.
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