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Product Description
Mechanism of Action
MITOMYCINE C (ID 26760) exhibits a deeply layered biochemical action profile involving coordinated modulation of enzyme-driven catalytic cascades, receptor-mediated signalling processes, intracellular ion dynamics, mitochondrial bioenergetics, membrane-potential stability and transcription-factor pathway regulation. Its molecular architecture supports high-affinity interaction with both catalytic and regulatory protein domains. These interactions allow the compound to influence phosphorylation–dephosphorylation cycles, reactive oxygen species (ROS) equilibrium, ATP turnover, calcium flux, and mitochondrial redox-state balance. In many experimental systems, MITOMYCINE C contributes to structural-protein reorganisation, cytoskeletal tension modulation and vesicular transport behaviour.
The compound may also affect chromatin accessibility and epigenetic markers, shifting transcriptional activity across multiple gene clusters involved in stress adaptation, metabolic steering and survival signalling. Such multi-dimensional mechanistic behaviour underlies its utility in complex research models.
Benefits and Advantages
MITOMYCINE C is suitable for a wide range of advanced laboratory research applications, including:
- Detailed receptor–ligand interaction mapping and affinity-modelling
- High-resolution enzymatic kinetic analysis and catalytic cascade mapping
- Mitochondrial-function assays, ATP-flux modelling and oxidative-stress monitoring
- Multi-omics systems: transcriptomics, proteomics, metabolomics and phosphoproteomics
- Cytoskeletal-dynamics research including actin–tubulin remodelling and mechanical signalling
- Apoptosis, necroptosis, ferroptosis and autophagy signalling studies
- SAR (structure–activity relationship) development and molecular-performance optimisation
- Advanced pharmacodynamic simulations and dose–response mechanistic modelling
Side Effects and Risks
Potential risks associated with MITOMYCINE C include:
- Oxidative-stress imbalance leading to ROS accumulation
- Mitochondrial overactivation or suppression of respiratory-chain complexes
- Ion-channel dysregulation affecting Ca²⁺/Na⁺/K⁺ homeostasis
- Unintended receptor cross-activation or inhibition
- Cytoskeletal destabilisation and membrane-integrity compromise
- Dose-dependent cytotoxicity, apoptosis, autophagy or metabolic-collapse signalling
- Activation of inflammatory transcriptional programmes (e.g., NF‑κB, p38 MAPK, JNK)
Prolonged exposure or excessive concentration may trigger transcriptional rewiring, altered metabolic routing, organelle stress responses, or epigenetic instability. Handle only under controlled laboratory conditions with appropriate biosafety procedures.
Datasheet
| Molecular Formula | C15H18N4O5 |
|---|---|
| Molecular Weight | 334.33 g/mol |
| CAS Number | 50-07-7 |
| Storage Condition | Mitomycin powder for injection should be protected from light and preferably stored at 15-30 °C: temperature greater than 40 °C should be avoided. |
| Solubility | Soluble (NTP, 1992) |
| Purity | Purity information is available upon request (COA). |
| Synonym | mitomycin C; Mitomycin; 50-07-7; Ametycine; Mutamycin |
| IUPAC/Chemical Name | [(4S,6S,7R,8S)-11-amino-7-methoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate |
| InChl Key | NWIBSHFKIJFRCO-WUDYKRTCSA-N |
| InChl Code | InChI=1S/C15H18N4O5/c1-5-9(16)12(21)8-6(4-24-14(17)22)15(23-2)13-7(18-13)3-19(15)10(8)11(5)20/h6-7,13,18H,3-4,16H2,1-2H3,(H2,17,22)/t6-,7+,13+,15-/m1/s1 |
| References |
3D Conformer.
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