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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
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Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Epirubicin is an anthracycline chemotherapeutic structurally related to doxorubicin but with reduced cardiotoxicity. It intercalates DNA, inhibits topoisomerase II, induces double‑strand breaks and generates free radicals, triggering apoptosis in rapidly dividing cells.
Benefits and Advantages
Used in DNA‑damage‑response research, oncologic model development, topoisomerase II inhibition assays, and anthracycline SAR studies.
Side Effects and Risks
Risks include myelosuppression, cardiomyopathy (dose‑dependent), alopecia, mucositis, red urine discoloration and necrosis upon extravasation. Handle with cytotoxic‑anthracycline precautions.
Datasheet
| Molecular Formula | C27H29NO11 |
|---|---|
| Molecular Weight | 543.5 g/mol |
| CAS Number | 56420-45-2 |
| Storage Condition | Store refrigerated between 2 °C and 8 °C (36 °F and 46 °F). Do not freeze. Protect from light. Storage of the solution for injection at refrigerated conditions can result in the formation of a gelled product. This gelled product will return to a slightly viscous to mobile solution after 2 to a maximum of 4 hours equilibration at controlled room temperature (15-25 °C). Solution for injection should be used within 24 hours after removal from refrigeration. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | Epirubicin; 56420-45-2; Epiadriamycin; Epidoxorubicin; 4'-Epiadriamycin |
| IUPAC/Chemical Name | (7S,9S)-7-[(2R,4S,5R,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione |
| InChl Key | AOJJSUZBOXZQNB-VTZDEGQISA-N |
| InChl Code | InChI=1S/C27H29NO11/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3/t10-,13-,15-,17-,22-,27-/m0/s1 |
| References |
3D Conformer.
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