About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Dactinomycin (actinomycin D) is an antitumour antibiotic that intercalates between adjacent guaninecytosine base pairs in DNA. This prevents RNA polymerase movement, blocks transcription initiation, and induces DNA strand breaks. It is highly potent against rapidly dividing cells and is a classical tool for transcriptioninhibition research.
Benefits and Advantages
Used in transcriptionblockade studies, DNAintercalation modelling, apoptosis signalling research, pediatrictumour models, and topoenzyme interaction assays.
Side Effects and Risks
Risks include profound myelosuppression, hepatotoxicity, mucositis, GI injury, cardiotoxicity and secondary malignancies. Handle with full cytotoxicagent containment.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C62H86N12O16 |
|---|---|
| Molecular Weight | 1255.4 g/mol |
| CAS Number | 50-76-0 |
| Storage Condition | Store at 25 °C (77deg F); excursions permitted to 15-30 °C (59-86 °F). Protect from light and humidity. |
| Solubility | Soluble at 50 °F (NTP, 1992) |
| Purity | Purity information is available upon request (COA). |
| Synonym | DACTINOMYCIN; actinomycin D; Actinomycin C1; Cosmegen; Actinomycin IV |
| IUPAC/Chemical Name | 2-amino-4,6-dimethyl-3-oxo-1-N,9-N-bis[(3R,6S,7R,10S,16S)-7,11,14-trimethyl-2,5,9,12,15-pentaoxo-3,10-di(propan-2-yl)-8-oxa-1,4,11,14-tetrazabicyclo[14.3.0]nonadecan-6-yl]phenoxazine-1,9-dicarboxamide |
| InChl Key | RJURFGZVJUQBHK-IIXSONLDSA-N |
| InChl Code | InChI=1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)/t33-,34-,36+,37+,42-,43-,44+,45+,48+,49+/m1/s1 |
| References |
3D Conformer.
(Click, turn or enlarge)
Download our GMP API Product List.
MedicaPharma is an EU-based supplier of GMP-certified APIs that serves leading healthcare institutions and research organizations.
Click here to download our full API product list.
