About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Dabrafenib is a selective inhibitor of mutant BRAF serinethreonine kinase, particularly BRAF V600E/K⁺. By binding the ATP pocket, it blocks aberrant MAPK/ERK signalling in tumour cells carrying these mutations, reducing proliferation and promoting apoptosis. It has limited activity on wildtype BRAF at therapeutic concentrations.
Benefits and Advantages
Used in oncogenicMAPK pathway research, BRAFmutant tumour modelling, kinaseinhibitor SAR studies, resistancemechanism analysis (e.g., MEK reactivation, NRAS mutations), and combination therapy research (e.g., with MEK inhibitors).
Side Effects and Risks
Risks include cutaneous squamouscell carcinomas, pyrexia, arthralgia, cardiomyopathy, uveitis and hepatotoxicity. Handle as a potent targeted kinase inhibitor with cytotoxic precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C23H20F2N4O2S2 |
|---|---|
| Molecular Weight | 519.6 g/mol |
| CAS Number | 1195765-45-7 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | very slightly soluble at pH 1 |
| Purity | Purity information is available upon request (COA). |
| Synonym | Dabrafenib; 1195765-45-7; GSK2118436A; GSK-2118436; QGP4HA4G1B |
| IUPAC/Chemical Name | N-[3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide |
| InChl Key | BFSMGDJOXZAERB-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C23H20F3N5O2S2/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29) |
| References |
3D Conformer.
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