About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
Network of over +400 GMP API producers
Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Cetuximab is a chimeric monoclonal IgG1 antibody targeting the epidermal growth factor receptor (EGFR). It binds the extracellular domain of EGFR, preventing ligand binding and inhibiting receptor dimerisation, internalisation and autophosphorylation. This suppresses downstream RAS/RAF/MEK/ERK and PI3K/AKT signalling, inhibiting proliferation, angiogenesis and tumourcell survival.
Benefits and Advantages
Used in EGFRpathway research, oncology models, cellsignalling studies, KRASmutation resistance investigations, antibodyreceptor binding kinetics, and monoclonalantibody pharmacology.
Side Effects and Risks
Risks include infusion reactions, severe acneiform rash, electrolyte imbalance (esp. hypomagnesaemia), interstitial lung disease and immunogenicity. Handle using biologicagent containment.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C6500H10176N1720O2024S42 |
|---|---|
| Molecular Weight | 152000.0 g/mol |
| CAS Number | 205923-56-4 |
| Storage Condition | Store in a cool, dry place; protected from light |
| Solubility | Soluble in water |
| Purity | Purity information is available upon request (COA). |
| Synonym | MLS002608064; CHEMBL1736329; HMS3092B19; AKOS024323068; isonicotinaldehyde O-(2-phenylethyl)oxime |
| IUPAC/Chemical Name | Chimeric monoclonal IgG1 antibody |
| InChl Key | Unavailable for large molecules |
| InChl Code | Unavailable for large molecules |
| References | PubChem; ChemBL; FDA substance registry; |
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