About MedicaPharma
MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
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Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of action
Capecitabine is an orally bioavailable prodrug converted to 5‑fluorouracil (5‑FU) through a cascade involving carboxylesterase, cytidine deaminase and thymidine phosphorylase. Its activation is enhanced in tumour tissues where thymidine phosphorylase is overexpressed. The active metabolite 5‑FU inhibits thymidylate synthase and incorporates into RNA/DNA, causing cytotoxicity.
Benefits and advantages
Used in oncology research, fluoropyrimidine metabolism studies, tumour-selective activation modelling, thymidylate-synthase inhibition assays, DNA-damage investigations and chemoresistance research.
Side effects and risks
Risks include myelosuppression, hand–foot syndrome, diarrhoea, mucositis, hepatotoxicity and cardiotoxicity. Requires strict cytotoxic-agent handling.
Datasheet
| Molecular Formula | C15H22FN3O6 |
|---|---|
| Molecular Weight | 359.35 g/mol |
| CAS Number | 154361-50-9 |
| Storage Condition | Capecitabine tablets should be stored in tightly closed containers at 25 °C but may be exposed to temperatures of 15-30 °C. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | CAPECITABINE; 154361-50-9; Xeloda; Capecitibine; Capiibine |
| IUPAC/Chemical Name | pentyl N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-2-oxopyrimidin-4-yl]carbamate |
| InChl Key | GAGWJHPBXLXJQN-UORFTKCHSA-N |
| InChl Code | InChI=1S/C15H22FN3O6/c1-3-4-5-6-24-15(23)18-12-9(16)7-19(14(22)17-12)13-11(21)10(20)8(2)25-13/h7-8,10-11,13,20-21H,3-6H2,1-2H3,(H,17,18,22,23)/t8-,10-,11-,13-/m1/s1 |
| References |
3D Conformer.
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