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Product Description
Mechanism of action
Bicalutamide is a non-steroidal androgen receptor (AR) antagonist that competitively inhibits binding of dihydrotestosterone (DHT) and testosterone to AR, preventing transcription of androgen-responsive genes. It blocks AR nuclear translocation and impairs coactivator recruitment, suppressing proliferation of androgen-dependent cells.
Benefits and advantages
Widely used in prostate-cancer research, AR signalling studies, endocrine-therapy modelling, resistance-mechanism investigation and structure–activity analysis of antiandrogens. A reference compound for evaluating next-generation AR degraders and inhibitors.
Side effects and risks
Risks include hepatotoxicity, gynecomastia, hot flushes, endocrine disruption, fatigue and QT prolongation. Handle using cytotoxic and hormonal-active compound containment.
Datasheet
| Molecular Formula | C18H14F4N2O4S |
|---|---|
| Molecular Weight | 430.4 g/mol |
| CAS Number | 90357-06-5 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | bicalutamide; 90357-06-5; Casodex; Cosudex; Calutide |
| IUPAC/Chemical Name | N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(4-fluorophenyl)sulfonyl-2-hydroxy-2-methylpropanamide |
| InChl Key | LKJPYSCBVHEWIU-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C18H14F4N2O4S/c1-17(26,10-29(27,28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25) |
| References |
3D Conformer.
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