10-DESACETYLBACCATIN
10‑Desacetylbaccatin is a taxane precursor used in the synthesis of paclitaxel analogues, stabilizing microtubules and inhibiting cell division. Benefits include essential use in anticancer drug manufacturing. Side effects relate to handling exposure and may include irritation or cytotoxicity in laboratory environments.
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Product Description
Mechanism of Action
10‑Desacetylbaccatin III is a crucial taxoid precursor extracted from *Taxus* species and serves as a semi‑synthetic scaffold for paclitaxel and docetaxel production. Its mechanism relates to microtubule stabilization through increased tubulin polymerization, though its direct cytotoxicity is lower than fully substituted taxanes.
Benefits and Advantages
Used in taxane‑biosynthesis research, anticancer drug precursor development, microtubule‑binding pathway studies, and natural‑product semi‑synthesis investigations.
Side Effects and Risks
Risks include mild cytotoxicity, dermatitis, ocular irritation and respiratory sensitization with powdered material. Handle with natural‑product precursor precautions.
Datasheet
| Molecular Formula | C29H36O10 |
|---|---|
| Molecular Weight | 560.6 g/mol |
| CAS Number | 32981-86-5 |
| Storage Condition | Store in a cool, dry place; protect from light |
| Solubility | Soluble in water |
| Purity | Purity information is available upon request (COA). |
| Synonym | Baccatin III; 27548-93-2; 40K5PZ0K67; 7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,9,11-trihydroxy-4a,8,13,13-tetramethyl-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-; CHEBI:32898 |
| IUPAC/Chemical Name | (2α,5α,10β,13α)-4,10-bis(acetyloxy)-1,7,13-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate |
| InChl Key | Unavailable |
| InChl Code | Unavailable |
| References | PubChem; ChemBL; FDA; |
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