10-DESACETYLBACCATIN
10Desacetylbaccatin is a taxane precursor used in the synthesis of paclitaxel analogues, stabilizing microtubules and inhibiting cell division. Benefits include essential use in anticancer drug manufacturing. Side effects relate to handling exposure and may include irritation or cytotoxicity in laboratory environments. Only GMP materials will be supplied, logistics all according to GDP.
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Product Description
Mechanism of Action
10Desacetylbaccatin III is a crucial taxoid precursor extracted from *Taxus* species and serves as a semisynthetic scaffold for paclitaxel and docetaxel production. Its mechanism relates to microtubule stabilization through increased tubulin polymerization, though its direct cytotoxicity is lower than fully substituted taxanes.
Benefits and Advantages
Used in taxanebiosynthesis research, anticancer drug precursor development, microtubulebinding pathway studies, and naturalproduct semisynthesis investigations.
Side Effects and Risks
Risks include mild cytotoxicity, dermatitis, ocular irritation and respiratory sensitization with powdered material. Handle with naturalproduct precursor precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C29H36O10 |
|---|---|
| Molecular Weight | 560.6 g/mol |
| CAS Number | 32981-86-5 |
| Storage Condition | Store in a cool, dry place; protect from light |
| Solubility | Soluble in water |
| Purity | Purity information is available upon request (COA). |
| Synonym | Baccatin III; 27548-93-2; 40K5PZ0K67; 7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one, 6,12b-bis(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,9,11-trihydroxy-4a,8,13,13-tetramethyl-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-; CHEBI:32898 |
| IUPAC/Chemical Name | (2α,5α,10β,13α)-4,10-bis(acetyloxy)-1,7,13-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate |
| InChl Key | Unavailable |
| InChl Code | Unavailable |
| References | PubChem; ChemBL; FDA; |
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