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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
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Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Dicumarol is a naturally derived anticoagulant and the prototype vitaminK antagonist. It inhibits vitaminK epoxide reductase (VKOR), preventing the regeneration of reduced vitamin K⁺ needed for carboxylation of clotting factors II, VII, IX, and X. This decreases thrombin formation and disrupts the coagulation cascade.
Benefits and Advantages
Used in anticoagulationpathway research, VKOR inhibition studies, clottingfactor biosynthesis modelling, and structureactivity analysis of coumarin derivatives.
Side Effects and Risks
Risks include bleeding, hepatic dysfunction, drugdrug interactions, skin necrosis (rare) and teratogenicity. Handle with anticoagulantclass precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C19H12O6 |
|---|---|
| Molecular Weight | 336.3 g/mol |
| CAS Number | 66-76-2 |
| Storage Condition | Dicumarol should be stored in well-closed containers at a temperature below 40 degrees C (104 °F), preferably 15 to 30 °C (59 to 86 °F), and kept away from direct sunlight. The manufacturer recommends storage below 25 °C (77 °F). |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | dicumarol; dicoumarol; 66-76-2; Bishydroxycoumarin; melitoxin |
| IUPAC/Chemical Name | 4-hydroxy-3-[(4-hydroxy-2-oxochromen-3-yl)methyl]chromen-2-one |
| InChl Key | DOBMPNYZJYQDGZ-UHFFFAOYSA-N |
| InChl Code | InChI=1S/C19H12O6/c20-16-10-5-1-3-7-14(10)24-18(22)12(16)9-13-17(21)11-6-2-4-8-15(11)25-19(13)23/h1-8,20-21H,9H2 |
| References |
3D Conformer.
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