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MedicaPharma distributes high-quality active pharmaceutical ingredients (APIs) to hospitals, commercial (compounding) pharmacies, research institutes, and universities worldwide.
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Let us handle your sourcing / supply activities. Highly experienced in sourcing specialty raw pharmaceutical ingredients from niche GMP manufacturers around the world.
Why Choose MedicaPharma
Niche API specialist - Pro-active supply partner - High service level - Global network - Logistics according to GDP regulations
Product Description
Mechanism of Action
Cotinine is the primary metabolite of nicotine, produced via CYP2A6-mediated oxidation. It retains weak nicotinic acetylcholine receptor (nAChR) interaction and is widely used as a biomarker for nicotine exposure. Cotinine influences dopaminergic and cholinergic pathways subtly, with a long halflife suitable for pharmacokinetic modelling.
Benefits and Advantages
Used in nicotinemetabolism research, addictionpathway studies, exposurebiomarker development, CYP2A6 enzyme kinetics, neuropharmacology assays and epidemiologic modelling of tobacco metabolites.
Side Effects and Risks
Risks include mild cardiovascular stimulation, cholinergic effects and CNS alterations at high concentrations. Handle with nicotinemetabolite precautions.
Only GMP materials will be supplied, logistics all according to GDP.
Datasheet
| Molecular Formula | C10H12N2O |
|---|---|
| Molecular Weight | 176.21 g/mol |
| CAS Number | 486-56-6 |
| Storage Condition | Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light. |
| Solubility | Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance. |
| Purity | Purity information is available upon request (COA). |
| Synonym | cotinine; (-)-Cotinine; 486-56-6; (S)-Cotinine; Cotinina |
| IUPAC/Chemical Name | (5S)-1-methyl-5-pyridin-3-ylpyrrolidin-2-one |
| InChl Key | UIKROCXWUNQSPJ-VIFPVBQESA-N |
| InChl Code | InChI=1S/C10H12N2O/c1-12-9(4-5-10(12)13)8-3-2-6-11-7-8/h2-3,6-7,9H,4-5H2,1H3/t9-/m0/s1 |
| References |
3D Conformer.
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